142991-33-1Relevant academic research and scientific papers
Stereoselective reactions of α,β-epoxy-aldehydes; the formation of "chelation controlled" products
Wang, Shouming,Howe, Graham P.,Mahal, Ravinderjit S.,Procter, Garry
, p. 3351 - 3354 (2007/10/02)
Treatment of the α,β-epoxy-aldehydes (l) and (2) with Lewis acids followed by in situ reaction with carbon nucleophiles produces halohydrins of the products of "chelation controlled" addition to the aldehyde with high diastereoselectivity; The regiochemistry of epoxide opening is determined by choice of Lewis acid.
