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1429940-04-4

(5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • (5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

    Cas No: 1429940-04-4

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  • 1429940-04-4 Structure

  • Basic information

    1. Product Name: (5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid
    2. Synonyms:
    3. CAS NO:1429940-04-4
    4. Molecular Formula:
    5. Molecular Weight: 327.263
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1429940-04-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: (5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid(1429940-04-4)
    11. EPA Substance Registry System: (5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid(1429940-04-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1429940-04-4(Hazardous Substances Data)

1429940-04-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1429940-04-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,9,9,4 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1429940-04:
(9*1)+(8*4)+(7*2)+(6*9)+(5*9)+(4*4)+(3*0)+(2*0)+(1*4)=174
174 % 10 = 4
So 1429940-04-4 is a valid CAS Registry Number.

1429940-04-4Relevant articles and documents

Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents

Yokokawa, Fumiaki,Wang, Gang,Chan, Wai Ling,Ang, Shi Hua,Wong, Josephine,Ma, Ida,Rao, Srinivasa P. S.,Manjunatha, Ujjini,Lakshminarayana, Suresh B.,Herve, Maxime,Kounde, Cyrille,Tan, Bee Huat,Thayalan, Pamela,Ng, Seow Hwee,Nanjundappa, Mahesh,Ravindran, Sindhu,Gee, Peck,Tan, Maria,Wei, Liu,Goh, Anne,Chen, Pei-Yu,Lee, Kok Sin,Zhong, Chen,Wagner, Trixie,Dix, Ina,Chatterjee, Arnab K.,Pethe, Kevin,Kuhen, Kelli,Glynne, Richard,Smith, Paul,Bifani, Pablo,Jiricek, Jan

, p. 451 - 455 (2013/07/11)

Tetrahydropyrazolo[1,5-a]pyrimidine scaffold was identified as a hit series from a Mycobacterium tuberculosis (Mtb) whole cell high through-put screening (HTS) campaign. A series of derivatives of this class were synthesized to evaluate their structure-activity relationship (SAR) and structure-property relationship (SPR). Compound 9 had a promising in vivo DMPK profile in mouse and exhibited potent in vivo activity in a mouse efficacy model, achieving a reduction of 3.5 log CFU of Mtb after oral administration to infected mice once a day at 100 mg/kg for 28 days. Thus, compound 9 is a potential candidate for inclusion in combination therapies for both drug-sensitive and drug-resistant TB.

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