142995-31-1 Usage
Description
BOC-L-3-Trifluoromethylphe, also known as N-tert-butoxycarbonyl-3-trifluoromethyl-L-phenylalanine, is a synthetic chemical compound derived from the amino acid phenylalanine. It features a trifluoromethyl group that endows it with unique chemical and biological properties. BOC-L-3-Trifluoromethylphe is utilized in pharmaceutical research and development, serving as a building block for the synthesis of peptide-based drugs and as a tool in the development of new medicinal compounds. Its distinctive chemical structure and reactivity make it a valuable asset in the drug discovery and development processes.
Uses
Used in Pharmaceutical Research and Development:
BOC-L-3-Trifluoromethylphe is used as a building block for the synthesis of peptide-based drugs due to its unique chemical properties and reactivity. It contributes to the development of new medicinal compounds with enhanced pharmacological profiles.
Used in Drug Discovery:
BOC-L-3-Trifluoromethylphe is employed as a tool in drug discovery, aiding researchers in understanding the interactions between compounds and biological targets. Its distinct chemical structure allows for the exploration of novel mechanisms of action and the optimization of drug candidates for improved efficacy and safety.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, BOC-L-3-Trifluoromethylphe is used as a key intermediate in the synthesis of complex molecules with potential therapeutic applications. Its presence in these molecules can modulate their pharmacokinetic and pharmacodynamic properties, leading to the design of more effective drugs.
Used in Drug Synthesis:
BOC-L-3-Trifluoromethylphe is utilized in the synthesis of various drug candidates, particularly those targeting specific biological pathways or receptors. Its incorporation into these molecules can enhance their selectivity, potency, and stability, making them more suitable for clinical use.
Check Digit Verification of cas no
The CAS Registry Mumber 142995-31-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,2,9,9 and 5 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 142995-31:
(8*1)+(7*4)+(6*2)+(5*9)+(4*9)+(3*5)+(2*3)+(1*1)=151
151 % 10 = 1
So 142995-31-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H18F3NO4/c1-14(2,3)23-13(22)19-11(12(20)21)8-9-5-4-6-10(7-9)15(16,17)18/h4-7,11H,8H2,1-3H3,(H,19,22)(H,20,21)/t11-/m0/s1
142995-31-1Relevant articles and documents
Studies of Neurokinin Antagonists. 4. Synthesis and Structure-Activity Relationships of Novel Dipeptide Substance P Antagonists: N2--L-prolyl>-N-methyl-N-(phenylmethyl)-3-(2-naphthyl)-L-alaninamide and Its Related Compounds
Hagiwara, Daijiro,Miyake, Hiroshi,Igari, Norihiro,Karino, Masako,Maeda, Yasue,et al.
, p. 2090 - 2099 (2007/10/02)
As an extension of our studies on discovering a novel substance P (SP) antagonist, we modified the previously reported dipeptide, N2-2-(1H-indol-3-ylcarbonyl)-L-lysyl>-N-methyl-N-(phenylmethyl)-L-phenylalaninamide (2b).The lysine part in 2b was first optimized to a (2S,4R)-hydroxyproline derivative (3h), which is 2-fold more potent than 2b in SP binding assay using guinea pig lung membranes.Next we modified the 1H-indol-3-ylcarbonyl part in 3h.Introduction of a methyl group at the indole nitrogen enhanced the oral activity, while retaining the binding activity.Finally, we modified the phenylalanine part to culminate in the most potent compound 7k (FK888), which is a potent SP antagonist with NK1 selectivity as well as oral activity.
