1430067-39-2

Basic information

• Product Name: α-1-O-triisopropylsilyl-2-deoxy-2-fluoro-3,5-di-O-benzoyl-D-arabinofuranose
• Synonyms: α-1-O-triisopropylsilyl-2-deoxy-2-fluoro-3,5-di-O-benzoyl-D-arabinofuranose
• CAS NO: 1430067-39-2
• Molecular Weight: 516.682
• Mol File: 1430067-39-2.mol

Chemical Properties

• CAS DataBase Reference: α-1-O-triisopropylsilyl-2-deoxy-2-fluoro-3,5-di-O-benzoyl-D-arabinofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: α-1-O-triisopropylsilyl-2-deoxy-2-fluoro-3,5-di-O-benzoyl-D-arabinofuranose(1430067-39-2)
• EPA Substance Registry System: α-1-O-triisopropylsilyl-2-deoxy-2-fluoro-3,5-di-O-benzoyl-D-arabinofuranose(1430067-39-2)

Safety Data

• Hazardous Substances Data: 1430067-39-2(Hazardous Substances Data)

Upstream product

• 97614-43-2 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose 
• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 

Relevant articles and documents

Synthesis and biological evaluation of prodrugs of 2-fluoro-2-deoxyribose- 1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate

We report in this Letter the synthesis of prodrugs of 2-fluoro-2- deoxyarabinose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate. We demonstrate the difficulty of realising a phosphorylation step on the anomeric position of 2-deoxyribose, and we discover that introduction of fluorine atoms on the 2 position of 2-deoxyribose enables the phosphorylation step: in fact, the stability of the prodrugs increases with the degree of 2-fluorination. Stability studies of produgs of 2-fluoro-2-deoxyribose-1-phosphate and 2,2-difluoro-2-deoxyribose-1-phosphate in acidic and neutral conditions were conducted to confirm our observation. Biological evaluation of prodrugs of 2,2-difluoro-2-deoxyribose-1-phosphate for antiviral and cytotoxic activity is reported.