1430075-34-5Relevant academic research and scientific papers
Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series
Cox, Jason M.,Chu, Hong D.,Yang, Christine,Shen, Hong C.,Wu, Zhicai,Balsells, Jaume,Crespo, Alejandro,Brown, Patricia,Zamlynny, Beata,Wiltsie, Judyann,Clemas, Joseph,Gibson, Jack,Contino, Lisa,Lisnock, Jeanmarie,Zhou, Gaochao,Garcia-Calvo, Margarita,Bateman, Thomas,Xu, Ling,Tong, Xinchun,Crook, Martin,Sinclair, Peter
, p. 1681 - 1684 (2014/04/17)
Novel potent and selective mineralocorticoid receptor antagonists were identified, utilizing heterocyclic amide replacements in the oxazolidinedione series. Structure-activity relationship (SAR) efforts focused on improving lipophilic ligand efficiency (LLE) while maintaining nuclear hormone receptor selectivity and reasonable pharmacokinetic profiles.
MINERALOCORTICOID RECEPTOR ANTAGONISTS
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Page/Page column 41; 42, (2013/04/25)
The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that are possible useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
