14301-34-9

Basic information

• Product Name: AcetaMide, 2,2,2-trichloro-N-(2-phenylethyl)-
• Synonyms: AcetaMide, 2,2,2-trichloro-N-(2-phenylethyl)-;2,2,2-trichloro-N-(2-phenylethyl)acetamide
• CAS NO: 14301-34-9
• Molecular Formula: C₁₀H₁₀Cl₃NO
• Molecular Weight: 266.5515
• Mol File: 14301-34-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AcetaMide, 2,2,2-trichloro-N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: AcetaMide, 2,2,2-trichloro-N-(2-phenylethyl)-(14301-34-9)
• EPA Substance Registry System: AcetaMide, 2,2,2-trichloro-N-(2-phenylethyl)-(14301-34-9)

Safety Data

• Hazardous Substances Data: 14301-34-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
AcetaMide, 2,2,2-trichloro-N-(2-phenylethyl)is used as an intermediate in the synthesis of pharmaceuticals for its mild analgesic and antipyretic properties. It aids in the development of medications aimed at alleviating pain and reducing fever, making it a valuable component in the formulation of certain therapeutic agents.
Used in Organic Synthesis:
In the field of organic chemistry, AcetaMide, 2,2,2-trichloro-N-(2-phenylethyl)serves as a key intermediate. It is employed in the creation of diverse organic compounds, contributing to the advancement of chemical research and the production of specialty chemicals for various applications.

Upstream product

• 116-16-5 1,1,1,3,3,3-hexachloro-propan-2-one 
• 64-04-0 phenethylamine 
• 515-84-4 Ethyl trichloroacetate 
• 99421-73-5 β-phenylethyl trichloroacetimidate 
• 76-02-8 trifluoroacetyl chloride 

Relevant articles and documents

Synthesis, biological activities and docking studies of pleuromutilin derivatives with piperazinyl urea linkage

Antibiotics resistance is becoming increasingly common, involving almost all antibiotics on the market. Diseases caused by drug resistant bacteria, such as MRSA, have high mortality and negatively affect public health. The development of new drugs would be an effective means of solving this problem. Modifications based on bioactive natural products could greatly shorten drug development time and improve success rate. Pleuromutilin, a natural product from the basidiomycete bacterial species, is a promising antibiotic candidate. In this study, a series of novel pleuromutilin derivatives possessing piperazinyl urea linkage were efficiently synthesised, and their antibacterial activities and bactericidal properties were evaluated via MIC, MBC and Time-kill kinetics assays. The results showed that all compounds exhibited potent activities against tested strains, especially MRSA strains with MIC values as low as 0.125 μg/mL; 8 times lower than that of marketed antibiotic Tiamulin. Docking studies indicate substituted piperazinyl urea derivatives could provide hydrogen bonds and initiate π-π stacking between molecules and surrounding residues.