1430200-27-3

Basic information

• Product Name: (5R)-5-benzyl-5-(5-bromo-1H-benzimidazol-2-yl)-3-[(1R)-1-(4-fluorophenyl)ethyl]-1,3-oxazolidine-2,4-dione
• Synonyms: (5R)-5-benzyl-5-(5-bromo-1H-benzimidazol-2-yl)-3-[(1R)-1-(4-fluorophenyl)ethyl]-1,3-oxazolidine-2,4-dione
• CAS NO: 1430200-27-3
• Molecular Weight: 508.347
• Mol File: 1430200-27-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (5R)-5-benzyl-5-(5-bromo-1H-benzimidazol-2-yl)-3-[(1R)-1-(4-fluorophenyl)ethyl]-1,3-oxazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (5R)-5-benzyl-5-(5-bromo-1H-benzimidazol-2-yl)-3-[(1R)-1-(4-fluorophenyl)ethyl]-1,3-oxazolidine-2,4-dione(1430200-27-3)
• EPA Substance Registry System: (5R)-5-benzyl-5-(5-bromo-1H-benzimidazol-2-yl)-3-[(1R)-1-(4-fluorophenyl)ethyl]-1,3-oxazolidine-2,4-dione(1430200-27-3)

Safety Data

• Hazardous Substances Data: 1430200-27-3(Hazardous Substances Data)

Upstream product

• 1430104-90-7 (2R)-2-benzyl-3-ethoxy-2-hydroxy-3-oxopropanoic acid 
• 252730-57-7 2-benzyl-3-ethoxy-2-hydroxy-3-oxopropanoic acid 
• 56150-08-4 diethyl α-benzyl α-hydroxymalonate 
• 607-81-8 diethyl 2-benzylmalonate 
• 745783-73-7 1-fluoro-4-[(1R)-1-isocyanatoethyl]-benzene 

Downstream Products

• 1430200-05-7 C₂₉H₂₂FN₅O₃ 
• 1430200-09-1 C₂₈H₂₂FN₅O₃ 
• 1430200-07-9 C₂₉H₂₄FN₅O₃ 
• 1430200-08-0 C₃₀H₂₃FN₄O₃ 

Relevant articles and documents

Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists

Elaboration of the oxazolidinedione series led to replacement of the exocyclic amides with substituted benzimidazoles. The structure-activity relationship (SAR) exploration resulted in the discovery of potent and selective nonsteroidal mineralocorticoid receptor (MR) antagonists with significantly improved microsomal stability and pharmacokinetic (PK) profile relative to the HTS hit 1a. One compound 2p possessed comparable efficacy as spironolactone (SPL) at 100 mg/kg (p.o.) in the rat natriuresis model. As such, this series was validated as a lead series for further optimization.