1430208-75-5Relevant academic research and scientific papers
Development of an Improved Guanidine-Based Rac1 Inhibitor with in vivo Activity against Non-Small Cell Lung Cancer
Ciarlantini, Matías S.,Barquero, Andrea,Bayo, Juan,Wetzler, Diana,Dodes Traian, Martín M.,Bucci, Hernán A.,Fiore, Esteban J.,Gandolfi Donadío, Lucía,Defelipe, Lucas,Turjanski, Adrián,Ramírez, Javier A.,Mazzolini, Guillermo,Comin, Maria J.
, p. 1011 - 1021 (2021)
The Rho GTPase Rac1 is involved in the control of cytoskeleton reorganization and other fundamental cellular functions. Aberrant activity of Rac1 and its regulators is common in human cancer. In particular, deregulated expression/activity of Rac GEFs, res
PHENYL-GUANIDINE DERIVATIVES
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Page/Page column 24; 25, (2013/04/25)
Provided herein are phenyl-guanidine derivatives for the inhibition of Rac1 which blocks its interaction with guanosine exchange factors (GEFs) belonging to the DBL family as agents for the treatment of aggressive and/or resistant tumours, as well as pharmaceutical compositions comprising them, their use in therapy and processes for their preparation.
