1430228-85-5

Basic information

• Product Name: 2-(3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole
• Synonyms: 2-(3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole
• CAS NO: 1430228-85-5
• Molecular Weight: 526.323
• Mol File: 1430228-85-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole(1430228-85-5)
• EPA Substance Registry System: 2-(3-(4-chlorophenyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(6-chlorocoumarin-3-yl)thiazole(1430228-85-5)

Safety Data

• Hazardous Substances Data: 1430228-85-5(Hazardous Substances Data)

Upstream product

• 2420-26-0 4-chlorosalicylaldehyde 
• 53653-66-0 3-acetyl-6-chlorocoumarin 
• 443749-40-4 5-hydroxy-3-(p-chlorophenyl)-5-trifluoromethyl-4,5-dihydropyrazol-1-thiocarboxamide 
• 106577-99-5 3-(2-bromoacetyl)-6-chloro-2H-chromen-2-one 
• 18931-60-7 1-(4-chlorophenyl)-4,4,4-trifluorobutane-1,3-dione 

Relevant articles and documents

Synthesis and pharmacological evaluation of some novel 2-(5-hydroxy-5- trifluoromethyl-4,5-dihydropyrazol-1-yl)-4-(coumarin-3-yl)thiazoles

A series of novel 2-(5-hydroxy-5-trifluoromethyl-4,5-dihydropyrazol-1-yl)- 4-(coumarin-3-yl)thiazoles (6) were synthesized by condensing 3-(2-bromoacetyl)coumarins (4) with various 5-hydroxy-5-trifluoromethyl-4,5- dihydropyrazol-1-thiocarboxamides (5), obtained by the reaction of thiosemicarbazide with trifluoromethyl-β-diketones. All the tested compounds displayed significant to moderate in vivo anti-inflammatory activity when compared to the standard drug indomethacin, and good broad spectrum in vitro antibacterial activity against three Gram-positive and four Gram-negative bacteria when compared with cefixime.