1430326-21-8

Basic information

• Product Name: (R)-N-(10-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)decyl)-1,2,3,4-tetrahydroacridin-9-amine
• Synonyms: (R)-N-(10-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)decyl)-1,2,3,4-tetrahydroacridin-9-amine
• CAS NO: 1430326-21-8
• Molecular Weight: 539.805
• Mol File: 1430326-21-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N-(10-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)decyl)-1,2,3,4-tetrahydroacridin-9-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N-(10-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)decyl)-1,2,3,4-tetrahydroacridin-9-amine(1430326-21-8)
• EPA Substance Registry System: (R)-N-(10-(4-(2-(methyl(prop-2-ynyl)amino)propyl)phenoxy)decyl)-1,2,3,4-tetrahydroacridin-9-amine(1430326-21-8)

Safety Data

• Hazardous Substances Data: 1430326-21-8(Hazardous Substances Data)

Upstream product

• 122-84-9 4-methoxybenzyl methyl ketone 
• 58993-79-6 (R)-(-)-p-methoxyamphetamine 
• 140173-30-4 (R)-1-(4-methoxyphenyl)-N-((R)-1-phenylethyl)propan-2-amine 
• 321-64-2 tacrin 
• 1430326-13-8 (R)-N-(1-(4-(10-bromodecyloxy)phenyl)propan-2-yl)-N-methylprop-2-yn-1-amine 
• 1430326-05-8 (R)-N-(1-(4-methoxyphenyl)propan-2-yl)-N-methylprop-2-yn-1-amine 
• 1430326-04-7 (R)-N-(1-(4-methoxyphenyl)propan-2-yl)prop-2-yn-1-amine 

Relevant articles and documents

A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease

A novel series of tacrine-selegiline hybrids was synthesised and evaluated for application as inhibitors of cholinesterase (AChE/BuChE) and monoamine oxidase (MAO-A/B). The results demonstrate that most of the synthesised compounds exhibit high inhibitory activity. Among these compounds, compound 8g provided a good balance of activity towards all targets (with IC50 values of 22.6 nM, 9.37 nM, 0.3724 μM, and 0.1810 μM for AChE, BuChE, MAO-A and MAO-B, respectively). These results indicated that 8g has the potential to be a multi-functional candidate for Alzheimer's disease.