1430342-25-8

Basic information

• Product Name: 2-(4-methoxyphenyl)-3-hydroxy-1-phenylpropan-1-one
• Synonyms: 2-(4-methoxyphenyl)-3-hydroxy-1-phenylpropan-1-one
• CAS NO: 1430342-25-8
• Molecular Weight: 256.301
• Mol File: 1430342-25-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-3-hydroxy-1-phenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-3-hydroxy-1-phenylpropan-1-one(1430342-25-8)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-3-hydroxy-1-phenylpropan-1-one(1430342-25-8)

Safety Data

• Hazardous Substances Data: 1430342-25-8(Hazardous Substances Data)

Upstream product

• 25826-75-9 2-(4-methoxyphenyl)-3-oxo-3-phenylpropanal 
• 6969-02-4 [3-(4-methoxyphenyl)oxiran-2-yl]phenylmethanone 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 1504-58-1 3-Phenyl-2-propyn-1-ol 
• 1330681-27-0 (4-methoxyphenyl)(mesityl)iodonium trifluoromethanesulfonate 

Relevant articles and documents

Metal-free, one-pot, sequential protocol for transforming ,-epoxy ketones to -hydroxy ketones and -methylene ketones

A new sequential, one-pot protocol for transforming 1,3-disubstituted 2,3-epoxy ketones to β;-hydroxy ketones and α-methylene ketones has been developed. Reaction of epoxy ketones with boron trifluoride etherate (BF3·OEt2) generates the cationic intermediates by regioselective epoxide ring opening and an acyl shift. Then, a treatment of these cations with 2-aryl-1,3-dimethylbenzimidazolines (DMBIH) results in formation of 1,2-disubstituted 3-hydroxy ketones. DMBIH serves as a hydride donor in the second step of this process. Finally, the β;-hydroxy ketones can be converted to 1,2-disubstituted 2-methylene ketones by treatment with methanesulfonic acid or a combination of methanesulfonyl chloride and triethylamine. Importantly, the sequential steps involved in formation of the α-methylene ketone products can be carried out in one pot.