1430423-76-9Relevant academic research and scientific papers
Metal-free fluorination of C(sp3)-H bonds using a catalytic N-oxyl radical
Amaoka, Yuuki,Nagatomo, Masanori,Inoue, Masayuki
supporting information, p. 2160 - 2163 (2013/06/05)
A direct conversion of C(sp3)-H bonds to C(sp3)-F bonds has been developed. In this process, a catalytic N-oxyl radical generated from N,N-dihydroxypyromellitimide abstracts hydrogen from the C(sp 3)-H bond and Selectfluor acts to trap the resulting carbon radical to form the C(sp3)-F bond. This simple metal-free protocol enables the chemoselective introduction of a fluorine atom into various aromatic and aliphatic compounds and serves as a powerful tool for the efficient synthesis of fluorinated molecules.
