1430475-90-3Relevant academic research and scientific papers
Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors
Chandrasekharappa, Arun P.,Badiger, Sangamesh E.,Dubey, Pramod K.,Panigrahi, Sunil K.,Manukonda, Sekhar Reddy V.V.V.
, p. 2579 - 2584 (2013/06/27)
A series of benzoxazole compounds containing oxamic acid were synthesized and screened for the PTP1B inhibition. Compound 31d showed best biochemical potency (Ki) of 6.7 μM. Structure-activity relationship were explained with the help of molecular modeling approach.
