1430747-40-2Relevant academic research and scientific papers
Development of Plowast-monodentate diamidophosphites with a C1-symmetric 1,2-diamine backbone: The effects of substituents in the 1,3,2-diazaphospholidine cycle on Pd-catalyzed asymmetric allylations
Gavrilov, Konstantin N.,Shiryaev, Alexei A.,Zheglov, Sergey V.,Potapova, Oksana V.,Chuchelkin, Ilya V.,Novikov, Ivan M.,Rastorguev, Eugenie A.,Davankov, Vadim A.
, p. 409 - 417 (2013)
We have designed and synthesized a small library of modular monodentate diamidophosphite ligands with stereogenic phosphorus atoms. The library was prepared efficiently from the commercially available and inexpensive (S)-N-Boc-amino acids. These novel ligands were screened in the Pd-catalyzed asymmetric allylations of (E)-1,3-diphenylallyl acetate with dimethyl malonate as the C-nucleophile with up to 93% ee being obtained. The results showed that the different substituents in the 1,3,2-diazaphospholidine cycle had remarkable effects on the enantioselectivity.
