143076-53-3Relevant academic research and scientific papers
Stereocontrolled synthesis of oxaspirobicycles via prins-pinacol annulation
Chavre, Satish N.,Ullapu, Punna Reddy,Min, Sun-Joon,Lee, Jae Kyun,Pae, Ae Nim,Kim, Youseung,Cho, Yong Seo
supporting information; scheme or table, p. 3834 - 3837 (2009/12/06)
We have developed the stereoselective synthesis of 2-oxaspiro[m,n]alkane derivatives using the Prins-pinacol annulation of alkene diols with a wide range of aliphatic or aromatic aldehydes and ketones. This approach was further applied for the synthesis o
Direct asymmetric α-hydroxylation of 2-hydroxymethyl ketones
Paju, Anne,Kanger, T?nis,Pehk, T?nis,Lopp, Margus
, p. 7321 - 7326 (2007/10/03)
A direct α-hydroxylation of racemic 2-hydroxymethyl ketones with the Sharpless epoxidation catalyst resulted in α,β-dihydroxy ketones in high ee (up to 97%) and in moderate to good isolated yield (up to 58%).
Direct asymmetric α-hydroxylation of β-hydroxyketones
Lopp, Margus,Paju, Anne,Kanger, Tonis,Pehk, Tonis
, p. 5051 - 5054 (2007/10/03)
Direct oxidation of racemic β-hydroxyketones 1a-c under Sharpless oxidation conditions resulted in the enantiomeric α,β-dihydroxyketones 2a in 97% ee, 2b in 86% ee and 2c in 95% ee respectively, in 37-58% of isolated yield. The oxidation is assumed to pro
