1430798-60-9

Basic information

• Product Name: C₃₁H₃₂Cl₂N₂O₅
• Synonyms: C₃₁H₃₂Cl₂N₂O₅
• CAS NO: 1430798-60-9
• Molecular Weight: 583.511
• Mol File: 1430798-60-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₃₁H₃₂Cl₂N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₁H₃₂Cl₂N₂O₅(1430798-60-9)
• EPA Substance Registry System: C₃₁H₃₂Cl₂N₂O₅(1430798-60-9)

Safety Data

• Hazardous Substances Data: 1430798-60-9(Hazardous Substances Data)

Upstream product

• 1221589-80-5 2,4-dichloro-1,5-diiodo-3-methoxybenzene 
• 1984-65-2 2,6-dichloroanisole 
• 1221589-79-2 2,2'-(4,6-dichloro-5-methoxy-1,3-phenylene)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) 
• 1430798-59-6 C₁₂H₁₄INO₂ 
• 1221589-81-6 (4,6-dichloro-5-methoxy-1,3-phenylene)bis(trimethylsilane) 

Downstream Products

• 1430798-61-0 10-methoxy-1,9-bis(4-methoxybenzyl)-4,6-dimethylpyrido[3,2-g]quinoline-2,8(1H,9H)-dione 

Relevant articles and documents

Synthetic studies on the reverse antibiotic natural products, the nybomycins

Antimicrobial resistance (AMR) is a serious issue that could have severe consequences if steps are not taken. The nybomycin natural products have the potential to extend the clinical efficacy of the marketed fluoroquinolone class of antibiotics through a 'reverse antibiotic' approach. However, only very limited structure-activity relationships are known for these fascinating compounds, in part due to challenges with their synthesis. Here we report a new scalable and robust synthetic route to the nybomycin natural products to aid in the development of this series. Through this synthesis, we report the antibiotic activity of novel analogues of this family confirming the selectivity for fluoroquinolone resistant bacteria and potential future opportunities for further optimisation.