1430841-87-4

Basic information

• Product Name: 2-(2-fluorobenzyloxy)benzaldehyde O-quinuclidin-3-yl oxime
• Synonyms: 2-(2-fluorobenzyloxy)benzaldehyde O-quinuclidin-3-yl oxime
• CAS NO: 1430841-87-4
• Molecular Weight: 354.424
• Mol File: 1430841-87-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-fluorobenzyloxy)benzaldehyde O-quinuclidin-3-yl oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorobenzyloxy)benzaldehyde O-quinuclidin-3-yl oxime(1430841-87-4)
• EPA Substance Registry System: 2-(2-fluorobenzyloxy)benzaldehyde O-quinuclidin-3-yl oxime(1430841-87-4)

Safety Data

• Hazardous Substances Data: 1430841-87-4(Hazardous Substances Data)

Upstream product

• 1619-34-7 3-quinuclidinol 
• 172685-66-4 2-((2-fluorobenzyl)oxy)benzaldehyde 
• 1430882-55-5 O-(quinuclidin-3-yl)hydroxylamine 
• 1430841-71-6 2-(quinuclidin-3-yloxy)isoindoline-1,3-dione 

Relevant articles and documents

Synthesis and evaluation of oxime derivatives as modulators for amyloid beta-induced mitochondrial dysfunction

Starting from quinuclidinyl oxime 1 identified by preliminary screening, a series of azacycles-containing oxime derivatives was synthesized. Their mPTP blocking activities were evaluated by a JC-1 assay, measuring the change of mitochondrial membrane potential. The inhibitory activity of nine compounds against amyloid beta-induced mPTP opening was comparable or even superior to that of piracetam. Among them, 12d effectively maintained mitochondrial function and cell viabilities on the ATP assay, the MTT assay, and the ROS assay. In addition, it exhibited favorable in vitro stability and pharmacokinetic characteristics, which hold a promise for further development of AD therapeutics.