143086-93-5

Upstream product

• 143168-25-6 [(2S,3S)-3-(Hydroxy-diphenyl-methyl)-1,4-dioxa-spiro[4.4]non-2-yl]-diphenyl-methanol; compound with N-isopropyl-N-methyl-2-oxo-2-phenyl-acetamide 
• 54044-70-1 5,5-dimethyl-3-phenyloxazolidin-2-one 
• 74-88-4 methyl iodide 
• 143086-89-9 N-Isopropyl-N-methyl-2-oxo-2-phenyl-acetamide 

Downstream Products

• 177089-31-5 5-Hydroxymethyl-2,2,3-trimethyl-5-phenyl-oxazolidin-4-one 

Relevant academic research and scientific papers

Synthesis and lipase-catalyzed resolution of 5-(hydroxymethyl)-1,3-dioxolan-4-ones: Masked glycerol analogs as potential building blocks for pharmaceuticals

(Hydroxymethyl)-1,3-dioxolan-4-ones from mandelic and lactic acids and 1,5,5-trimethyl-3-phenyloxazolidin-2-one from mandelamide were α-alkylated using benzyl chloromethyl ether. Reductive debenzylation of the products of alkylation unmasked the hydroxymethyl groups. The compounds obtained in this fashion were subsequently subjected to lipase-catalyzed resolution in organic media. Depending on the lipase and substrate employed, enantiomeric ratios up to E = 200 were observed. The obtained optically pure compounds can be considered as masked 2-substituted glycerol equivalents, which could be used for the preparation of tertiary (aryloxy)propanolamines, compounds having potential β-blocking activity.

Photocyclisation of Phenylglyoxylamides as Inclusion Complexes with an Optically Active Host Derived from Tartaric Acid: Delicate Dependence on the Substituent of the Host and Glyoxylamide

Optically active β-lactams and/or oxazolidinones have been obtained selectively by photoirradiation of a 1:2 inclusion complex of phenylglyoxylamide with an optically active host derived from tartaric acid.Delicate selectivity which is dependent on substituents in the phenylglyoxylamide and the host is described.