1431299-12-5

Basic information

• Product Name: C₁₂H₁₃F₃O₂
• CAS NO: 1431299-12-5
• Molecular Weight: 246.229
• Mol File: 1431299-12-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₃F₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₃F₃O₂(1431299-12-5)
• EPA Substance Registry System: C₁₂H₁₃F₃O₂(1431299-12-5)

Safety Data

• Hazardous Substances Data: 1431299-12-5(Hazardous Substances Data)

Upstream product

• 6117-80-2 1,4-butenediol 
• 454-87-5 3-(trifluoromethyl)benzenediazonium tetrafluoroborate 

Relevant articles and documents

Intermolecular enantioselective Heck-Matsuda arylations of acyclic olefins: Application to the synthesis of β-aryl-γ-lactones and β-aryl aldehydes

We describe herein a synthetically useful method for the enantioselective intermolecular Heck-Matsuda arylation of acyclic allylic alcohols. Aryldiazonium tetrafluoroborates were applied as arylating agents in the presence of Pd(TFA)2 and a chiral, commercially available, bisoxazoline ligand. The methodology is straightforward, robust, scalable up to a few grams, and of broad scope allowing the synthesis of a range of β-aryl-carbonyl compounds in good to high enantioselectivities and yields. This new enantioselective Heck-Matsuda arylation allowed the synthesis of β-aryl-γ-lactones and β-aryl aldehydes, which play a vital role as key intermediates in the synthesis of the biologically active compounds, such as (R)-baclofen, (R)-rolipram, (S)-curcumene, (S)-dehydrocurcumene, and (S)-tumerone.