1431324-42-3

Basic information

• Product Name: 6-(2,6-dichlorophenyl)-8-(4-methoxybenzyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one
• Synonyms: 6-(2,6-dichlorophenyl)-8-(4-methoxybenzyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one
• CAS NO: 1431324-42-3
• Molecular Weight: 458.368
• Mol File: 1431324-42-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-(2,6-dichlorophenyl)-8-(4-methoxybenzyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,6-dichlorophenyl)-8-(4-methoxybenzyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one(1431324-42-3)
• EPA Substance Registry System: 6-(2,6-dichlorophenyl)-8-(4-methoxybenzyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-5(8H)-one(1431324-42-3)

Safety Data

• Hazardous Substances Data: 1431324-42-3(Hazardous Substances Data)

Upstream product

• 1431323-75-9 1-(4-chloro-2-(methylthio)pyrimidin-5-yl)-2-(2,6-dichlorophenyl)ethanone 
• 397308-78-0 4-hydroxy-2-(methylsulfanyl)pyrimidine-5-carboxylic acid 
• 1431324-41-2 2-(2,6-dichlorophenyl)-1-(4-(4-methoxybenzylamino)-2-(methylthio)pyrimidin-5-yl)ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Relevant articles and documents

Investigation of biaryl heterocycles as inhibitors of Wee1 kinase

In continuation of our previous research towards the discovery of potent, selective and drug-like Wee1 inhibitors, 2 novel series of biaryl heterocycles were designed, synthesized and evaluated. The new biaryl cores were designed to enable structure?activ

PYRIDOPYRIMIDINONE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.