1431326-61-2 Usage
Uses
Used in Cancer Treatment:
LSD1-IN-1 is used as an inhibitor for the treatment of acute myeloid leukemia (AML). It targets AML stem cells, significantly reducing the tumor cell load and increasing survival time in mouse models of AML. The compound is currently in clinical trials for cancer treatment.
Used in Gene Regulation and Tumor Suppressor Activity:
LSD1-IN-1 is used as a research tool to study the role of LSD1 in gene regulation and the tumor suppressor activity of p53. By inhibiting LSD1, researchers can gain insights into the underlying mechanisms of various diseases and potentially develop novel therapeutic strategies.
Used in Drug Development:
LSD1-IN-1 serves as a starting point for the development of new drugs targeting LSD1. Its high potency and selectivity make it an attractive candidate for further optimization and development into more effective and safer therapeutic agents for various diseases, including cancer.
in vitro
ory-1001 is an enantiomerically pure kdm1a inhibitor with high selectivity against related fad dependent aminoxidases. ory-1001 does not inhibit non-related histone modifiers, and is clean in a cerep diversity panel. treatment of thp-1 cells with ory-1001, results in a time/dose dependent me2h3k4 accumulation at kdm1a target genes and concomitant induction of differentiation markers [1].
in vivo
daily oral administration of doses < 0.020 mg/kg leads to significantly reduced tumor growth in rodent xenografts. in vivo studies have shown that ory-1001 presents excellent oral bioavailability, target exposure and activity in vivo [1].
IC 50
<20nm
Check Digit Verification of cas no
The CAS Registry Mumber 1431326-61-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,1,3,2 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1431326-61:
(9*1)+(8*4)+(7*3)+(6*1)+(5*3)+(4*2)+(3*6)+(2*6)+(1*1)=122
122 % 10 = 2
So 1431326-61-2 is a valid CAS Registry Number.
1431326-61-2Relevant articles and documents
(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS
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Page/Page column 159, (2013/05/09)
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.
