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143136-91-8

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143136-91-8 Usage

Molecular weight

322.444 g/mol

Type of compound

Organic compound

Derivative of

Medroxyprogesterone (a synthetic progestin)

Applications

a. Development of contraceptive drugs
b. Hormone replacement therapies
c. Potential use in cancer treatment
d. Investigated as an antifungal agent

Biological activity

Potential biological activity; should be handled and used with caution in laboratory and clinical settings.

Check Digit Verification of cas no

The CAS Registry Mumber 143136-91-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,1,3 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 143136-91:
(8*1)+(7*4)+(6*3)+(5*1)+(4*3)+(3*6)+(2*9)+(1*1)=108
108 % 10 = 8
So 143136-91-8 is a valid CAS Registry Number.

143136-91-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4S*-Methyl-2R*-ethynyl-1,3-dioxane

1.2 Other means of identification

Product number -
Other names (2R,4S)-2-Ethynyl-4-methyl-[1,3]dioxane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:143136-91-8 SDS

143136-91-8Upstream product

143136-91-8Downstream Products

143136-91-8Relevant articles and documents

Synthesis and reactivity of chiral alkoxyallenes prepared by carbocupration of propargylic acetals.

Marek, I.,Alexakis, A.,Mangeney, P.,Normant, J. F.

, p. 171 - 190 (2007/10/02)

Chiral propargylic acetals are easily prepared with a chiral diol having a C2 axis of symmetry.They react highly diastereoselectively with Grignard reagents, under CuI catalysis, to afford axially chiral alkoxy allenes.The process is believed to involve a syn addition of the organometallic reagent across the triple bond, followed by a selective anti β-elimination of the alkoxy moiety next to the pseudoaxial substituent of the acetal ring.Although these chiral alkoxy allenes slowly racemize in the presence of CuI salts it is possible to slow down this processby addition of trivalent phosphorus ligands.In the absence of any copper salt, such preformed alkenyl organometallic reagents (Li, Mg) also undergo a highly diastereoselective β-elimination (de > 90percent).These chiral alkoxy allenes react further with lithium dialkyl cuprate to afford the E or Z enol ether (according to the reaction condition) leading, after hydrolysis, to chiral β-disubstituted aldehydes. Key Words: chiral diols / propargylic acetals / alkoxy allenes / organocuprates / enol ether E and Z / β-disubstituted aldehydes

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