143144-22-3Relevant academic research and scientific papers
Studies on the Use of Bidentate Ligands in the Directed Pauson-Khand Reaction
Krafft, Marie E.,Juliano, Carmelinda A.
, p. 5106 - 5115 (2007/10/02)
The use of bidentate ligands in the directed Pauson-Khand reaction was investigated.Substrates with a three-carbon linkage between the two heteroatoms gave better results than substrates containing two-carbon tethers.Higher yields and better regioselectivities were observed with thioamines and bisthioethers compared to diamines.Overall, only a few bidentate substrates showed marked improvements over previous results obtained with analogous monodentate compounds.Rationalizations based on the possible modes of cycloaddition operative for the various substrates studied are presented.
