1431463-01-2

Upstream product

• 6552-57-4 oxirane-d4 
• 5824-40-8 Triphenylmethylamin 

Downstream Products

• 1431463-03-4 N¹-tritylethane-1,1,2,2-d₄-1,2-diamine 
• 1431463-02-3 2-(2-(tritylamino)ethyl-1,1,2,2-d₄)isoindoline-1,3-dione 

Relevant academic research and scientific papers

SUBSTITUTED OXADIAZOLE CHEMICAL COMPOUND AND COMPOSITION CONTAINING SAID CHEMICAL COMPOUND AND USE THEREOF

Provided are a substituted oxadiazole chemical compound and composition containing said chemical compound and use thereof; said substituted oxadiazole chemical compound is the oxadiazole chemical compound as represented by formula (I), or its crystalline form, pharmaceutically acceptable salt, prodrug, stereoisomer, hydrate, or solvent compound. The disclosed substituted oxadiazole chemical compound and composition containing said chemical compound are capable of inhibiting indoleamine 2,3-dioxygenase; it also has better pharmacokinetic parameter attributes and is capable of improving the drug concentration of the chemical compound in an animal body, thus improving the therapeutic efficacy and safety of the drug.

Synthesis of N1-tritylethane-1,1,2,2-d4-1,2-diamine: A novel mono-protected C-deuterated ethylenediamine synthon

A convenient and high-yield synthesis for N1-tritylethane-1,1,2, 2-d4-1,2-diamine, a novel mono-protected ethylenediamine-C-d 4, is reported. N1-tritylethane-1,1,2,2-d 4-1,2-diamine was prepared in three steps from ethylene oxide-d 4 in a combined yield in the range 68-76%. Also reported is a synthesis of ethylenediamine-C-d4 in two steps from 1,2-dibromoethane-d4 in a combined yield in the range 61-65%. Published 2012. This article is a US Government work and is in the public domain in the USA.