1431463-27-2Relevant articles and documents
N-Isocyanimino-Triphenylphosphorane (Ph 3Pnnc) as an Efficient Reagent for the Preparation of Fully Substituted 1,3,4-Oxadiazoles via Intramolecular Aza-Wittig Reaction in Water
Jafari, Ali,Ramazani, Ali,Asiabi, Pegah Azimzadeh,Sadri, Fariba,Joo, Sang Woo
, p. 2246 - 2254 (2015)
An efficient green protocol for the synthesis of 1,3,4-oxadiazoles derivatives via a one-pot three-component reaction of aromatic carboxylic acids, N-isocyanimino-Triphenylphosphorane and ester derivatives of 2-oxopropyl alcohol (2-oxopropyl benzoate, 2-oxopropyl-4-bromobenzoate and 2-oxopropyl acetate) in water at room temperature have been developed. The present methodology offers several advantages such as a simple procedure, high yields, environmental friendliness and the absence of any volatile and hazardous organic solvents.
The reaction of N-isocyaniminotriphenylphosphorane with ester derivatives of 2-oxopropyl alcohol (2-Oxopropyl 4-Bromobenzoate, 2-Oxopropyl Benzoate, and 2-Oxopropyl Acetate) in the presence of aromatic carboxylic acids: A one-pot efficient three-component reaction for the synthesis of fully substituted 1,3,4-oxadiazole derivatives
Ramazani, Ali,Ahmadi, Yavar,Karimi, Zahra,Rezaei, Aram
, p. 1447 - 1451 (2013/02/23)
Reactions of N-isocyaniminotriphenylphosphorane with ester derivatives of 2-oxopropyl alcohol (2-oxopropyl 4-bromobenzoate, 2-oxopropyl benzoate, and 2-oxopropyl acetate) in the presence of aromatic carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions and no side reactions were observed.
