14315-23-2

Basic information

• Product Name: 3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE
• Synonyms: 3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE;CBI-BB ZERO/006491;OTAVA-BB 1056961;UKRORGSYN-BB BBV-027401;3-amino-N-(3-methylphenyl)benzamide(SALTDATA: FREE)
• CAS NO: 14315-23-2
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.28
• Mol File: 14315-23-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 95-97 °C(Solv: benzene (71-43-2))
• Boiling Point: 337.6°C at 760 mmHg
• Flash Point: 158°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0.000103mmHg at 25°C
• Refractive Index: 1.671
• PKA: 13.70±0.70(Predicted)
• CAS DataBase Reference: 3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE(14315-23-2)
• EPA Substance Registry System: 3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE(14315-23-2)

Safety Data

• Hazardous Substances Data: 14315-23-2(Hazardous Substances Data)

Usage

General Description

3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE is a chemical compound with the molecular formula C14H14N2O. It is commonly used as a research and experimental chemical in the field of organic synthesis and pharmaceutical development. 3-AMINO-N-(3-METHYLPHENYL)BENZAMIDE is classified as an amine and an amide, and it contains both an aromatic benzene ring and an amide functional group. Its specific properties and potential applications may vary depending on the intended use, but it is known to have various biological activities and potential pharmacological properties, making it a subject of interest for further study and exploration.

InChI:InChI=1/C14H14N2O/c1-10-4-2-7-13(8-10)16-14(17)11-5-3-6-12(15)9-11/h2-9H,15H2,1H3,(H,16,17)

Upstream product

• 121-90-4 m-nitrobenzoic acid chloride 
• 108-44-1 1-amino-3-methylbenzene 
• 69754-50-3 3-nitro-N-m-tolyl-benzamide 

Downstream Products

• 1233188-80-1 3-(2-chloro-acetylamino)-N-m-tolyl-benzamide 

Relevant articles and documents

Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17

Dual- or multi-target drugs are particularly promising for the treatment of complex diseases such as (neuro)inflammatory disorders. In the present study, we identified dual antagonists for two related pro-inflammatory G protein-coupled receptors (GPCRs), the purinergic receptor P2Y2 receptor, and the orphan receptor GPR17. Based on the lead compound suramin small molecules were designed, synthesized, and modified, including benzenesulfonate, benzenesulfonamide, dibenzamide and diphenylurea derivatives. Structure-activity relationship studies identified 3-nitrophenyl 4-benzamidobenzenesulfonic acid derivatives as dual P2Y2R/GPR17 antagonists. In particular, 3-nitrophenyl 4-(4-chlorobenzamido)benzenesulfonate (14l, IC50 3.01 μM at P2Y2R, and 3.37 μM at GPR17) and 3-nitrophenyl-4-(2-chlorobenzamido)benzenesulfonate (14m, IC50 3.17 μM at P2Y2R, and 1.67 μM at GPR17) exhibited dual antagonistic activity. Compound 14l was shown to act as an allosteric antagonist at both receptors. In addition, GPR17-selective antagonists were identified including 3-nitrophenyl 4-benzamidobenzenesulfonate (14a, IC50 3.20 μM) and 3-nitrophenyl 4-(3-(trifluoromethyl)benzamido)benzenesulfonate (14f, IC50 3.88 μM). The developed antagonists were selective versus other closely related P2Y receptors. They were found to possess high chemical and metabolic stability in human liver microsomes and therefore present good starting points for developing potent multi-target drugs with potential applications in inflammatory diseases.

Anticonvulsant activity of 2- and 3-aminobenzanilides

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