143150-92-9

Basic information

• Product Name: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
• Synonyms: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine;Thiazolo[5,4-c]pyridine, 2-broMo-4,5,6,7-tetrahydro-5-Methyl-;2-BroMo-5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine;2-bromo-5-methyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine;2-bromo-4,5,6,7-tetrahydro-5-methyl-Thiazolo[5,4-c]pyridine;2-bromo-5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
• CAS NO: 143150-92-9
• Molecular Formula: C₇H₉BrN₂S
• Molecular Weight: 233.12876
• Mol File: 143150-92-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 286.4±30.0 °C(Predicted)
• Appearance: /
• Density: 1.594±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly)
• PKA: 6.41±0.20(Predicted)
• CAS DataBase Reference: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine(143150-92-9)
• EPA Substance Registry System: 2-BroMo-5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine(143150-92-9)

Safety Data

• Hazardous Substances Data: 143150-92-9(Hazardous Substances Data)

Usage

General Description

2-Bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine is a chemical compound with the molecular formula C9H11BrN2S. The systematic name of this molecule is given as 2-Bromo-5-methyl-4,5,6,7-tetrahydro-1,3-thiazolo[5,4-c]pyridine. As per its chemical structure, the molecule consists of a bromo group attached at the second carbon, along with a methyl group at the fifth carbon of a tetrahydrothiazolo[5,4-c]pyridine ring structure. The nature, properties, uses, and potential applications of this chemical compound will depend upon its physical and chemical characteristics, which are influenced by the presence of these chemical groups.

Upstream product

• 50-00-0 formaldehyd 
• 365996-07-2 2-bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 365996-06-1 2-Bromo-5-tert-butoxycarbonyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine 
• 365996-05-0 tert-butyl 2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate 
• 852291-42-0 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine p-toluenesulfonate 
• 17899-48-8 2-amino-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine 
• 89580-42-7 3-bromo-1-methylpiperidin-4-one hydrobromide 
• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 720720-96-7 5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloric acid salt 
• 480449-71-6 [14C]-Edoxaban tosylate 
• 480449-70-5 edoxaban 
• 758685-72-2 5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid 
• 852291-42-0 2-bromo-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine p-toluenesulfonate 

Relevant articles and documents

Method for preparing edoxaban from trichloroacetophenone onium salt derivatives

The invention provides a method for preparing edoxaban by using 2, 2, 2-trichloro-1-(4, 5, 6, 7-tetrahydro-5-methylthiazolo[5, 4-c]pyridinium-1-yl) ethanone chloride. The preparation method comprisesthe following steps: preparing 2, 2, 2-trichloro-1-(4, 5, 6, 7-tetrahydro-5-methylthiazolo[5, 4-c]pyridinium-1-yl) ethanone chloride, namely 109C5-11; the invention discloses a preparation method of N1[(1S, 2R, 4S)-2-amino-4-[(dimethylamino) carbonyl]cyclohexyl]-N2(5-chloro-2-pyridyl) oxalamide dimesylate, namely 109T2-31. The 109C5-11 is used as an acylation reagent to prepare the edoxaban with 109T2-31. The preparation method comprises the following steps: preparing the edoxaban by using the 109C5-11 as the acylation reagent; the novel method overcomes the defect that expensive condensing agents EDCI.HCl and activating agents HOBt need to be used in the prior art. The new method provided by the invention is beneficial to more economically and more efficiently realizing industrial scale production of the Edoxaban p-toluenesulfonate hydrate.

METHOD FOR PRODUCING INHIBITOR OF ACTIVATED BLOOD COAGULATION FACTOR X (FXA)

An object of the present invention is to provide a novel method for producing a compound, a salt thereof, or a hydrate of the compound or the salt, which is an FXa inhibitor. The object can be attained by a production method in which a production method via a compound represented by formula (1-1), etc., from a compound represented by the following formula (1-x), etc., is used for a method for producing a compound represented by the following formula (X), etc. [wherein X represents a halogen atom or the like, and R1 represents an optionally substituted phenyl group].

TRIAMINE DERIVATIVE

An object of the present invention is to provide a novel compound which has a potent inhibitory effect on FXa and exhibits an excellent antithrombotic effect when orally administered. The present invention provides a compound represented by the following general formula (1): wherein R 1 and R 2 each independently represent a hydrogen atom, a hydroxy group, an alkyl group or an alkoxy group; Q 1 represents a saturated or unsaturated bicyclic or tricyclic fused hydrocarbon group which may be substituted, a saturated or unsaturated bicyclic or tricyclic fused heterocyclic group which may be substituted, or the like; Q 2 represents a single bond, a straight-chained or branched alkylene group having 1 to 6 carbon atoms, a straight-chained or branched alkenylene group having 2 to 6 carbon atoms, or the like; R 3 and R 4 each represent an alkyl group, or the like; m and n each represent an integer from 0 to 3; Q 4 represents an aryl group; and TDegree and T 1 each represent a carbonyl group or the like, and a medicine containing the compound.