1431542-29-8

Basic information

• Product Name: 3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester
• Synonyms: 3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester
• CAS NO: 1431542-29-8
• Molecular Weight: 357.206
• Mol File: 1431542-29-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester(1431542-29-8)
• EPA Substance Registry System: 3-(6-bromo-quinazolin-4-yl)-benzoic acid ethyl ester(1431542-29-8)

Safety Data

• Hazardous Substances Data: 1431542-29-8(Hazardous Substances Data)

Upstream product

• 32084-59-6 6-bromoquinazolin-4(3H)-one 
• 38267-96-8 6-bromo-4-chloroquinozoline 
• 4334-87-6 [3-(ethoxycarbonyl)phenyl]boronic acid 

Downstream Products

• 1431542-43-6 3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid ethyl ester 
• 1431541-84-2 (4-ethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone 
• 1431542-42-5 3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-benzoic acid 
• 1431541-95-5 {3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((R)-2-methyl-piperazin-1-yl)-methanone 
• 1431541-96-6 {3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone 
• 1431542-44-7 {3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-((S)-2-methyl-piperazin-1-yl)-methanone 
• 1431541-97-7 ((S)-2,4-dimethyl-piperazin-1-yl)-{3-[6-(6-methoxy-pyridin-3-yl)-quinazolin-4-yl]-phenyl}-methanone 
• 1443776-38-2 {3-[6-(4-methoxy-3-trifluoromethylphenyl)quinazolin-4-yl]phenyl}-(4-methylpiperazin-1-yl)methanone trifluoroacetate 
• 1431542-27-6 1-{4-[3-(6-bromo-quinazolin-4-yl)-benzoyl]-piperazine-1-yl}-ethanone 
• 1431540-99-6 5-{4-[3-(4-acetyl-piperazine-1-carbonyl)-phenyl]-quinazolin-6-yl}-2-methoxy-nicotinonitrile 
• 1431542-28-7 3-(6-bromo-quinazolin-4-yl)-benzoic acid 
• 1431542-30-1 [3-(6-bromo-quinazolin-4-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone 
• 1431541-32-0 2-methoxy-5-{4-[3-((R)-3-methylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}nicotinonitrile 
• 1431542-31-2 (R)-4-[3-(6-bromo-quinazolin-4-yl)-benzoyl]-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors

Inhibition of the lipid kinase PI3Kδ is a promising principle to treat B and T cell driven inflammatory diseases. Using a scaffold deconstruction-reconstruction strategy, we identified 4-aryl quinazolines that were optimized into potent PI3Kδ isoform selective analogues with good pharmacokinetic properties. With compound 11, we illustrate that biochemical PI3Kδ inhibition translates into modulation of isoform-dependent immune cell function (human, rat, and mouse). After oral administration of compound 11 to rats, proximal PD markers are inhibited, and dose-dependent efficacy in a mechanistic plaque forming cell assay could be demonstrated.

QUINAZOLINE DERIVATIVES AS PI3K MODULATORS

The invention relates to substituted quinazoline derivative of the formula (I), wherein A, X1, X2, X3, X4 and R5 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.