1431566-71-0

Basic information

• Product Name: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide
• Synonyms: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide
• CAS NO: 1431566-71-0
• Molecular Weight: 826.703
• Mol File: 1431566-71-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide(1431566-71-0)
• EPA Substance Registry System: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide(1431566-71-0)

Safety Data

• Hazardous Substances Data: 1431566-71-0(Hazardous Substances Data)

Upstream product

• 89-40-7 4-nitrophthalimide 
• 1038103-17-1 tert-butyl 2-(5-nitro-1,3-dioxoisoindolin-2-yl)acetate 
• 1431566-33-4 tert-butyl 2-(5-amino-1,3-dioxoisoindolin-2-yl)acetate 
• 1431566-70-9 2-(5-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetic acid 2,2,2-trifluoroacetic acid salt 
• 1431566-68-5 tert-butyl 2-(5-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate 
• 1431566-67-4 tert-butyl 2-(5-(N-(2-bromoethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate 
• 1431566-66-3 tert-butyl 2-(5-(N-(2-hydroxyethyl)-methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate 
• 1431566-34-5 tert-butyl 2-(5-(methylsulfonamido)-1,3-dioxoisoindolin-2-yl)acetate 

Relevant articles and documents

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS

Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/ or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.