143163-72-8 Usage
General Description
2-(Bromomethyl)-5-chlorobenzothiazole is a chemical compound with the molecular formula C8H5BrClNS. It is a benzothiazole derivative containing both bromomethyl and chloro substituents. 2-(BROMOMETHYL)-5-CHLOROBENZOTHIAZOLE is used primarily as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its potential applications in the field of medicinal chemistry, particularly in the development of biologically active molecules. Additionally, it is also utilized in the manufacturing of dyes, pigments, and other specialty chemicals. However, it is important to handle this compound with appropriate safety precautions, as it may pose hazards to human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 143163-72-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,1,6 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 143163-72:
(8*1)+(7*4)+(6*3)+(5*1)+(4*6)+(3*3)+(2*7)+(1*2)=108
108 % 10 = 8
So 143163-72-8 is a valid CAS Registry Number.
143163-72-8Relevant articles and documents
Highly selective aldose reductase inhibitors. II. Optimization of the aryl part of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids
Kotani, Takayuki,Ishii, Akira,Nagaki, Yasuhiro,Toyomaki, Yoshio,Yago, Hisashi,Suehiro, Seishi,Okukado, Nobuhisa,Okamoto, Kaoru
, p. 297 - 304 (2007/10/03)
Accumulation of intracellular sorbitol, the product of glucose reduction catalyzed by aldose reductase (AR) [EC 1.1.1.21], is thought to be the main culprit in the development of diabetic complications. A series of 3- arylalkyl-2,4,5-trioxoimidazolidine-1-acetic acids was prepared and tested for inhibitory activities towards AR and aldehyde reductase (ALR) [EC 1.1.1.2]. These derivatives showed strong inhibitory activity against AR without markedly inhibiting ALR. In particular, the compounds with 3- nitrophenyl, 4-chloro-3-nitrophenyl, and chloro-substituted benzothiazolyl groups as the aryl part showed powerful AR-inhibitory activity. The chloro- substituted benzothiazolyl compound showed an AR selectivity of more than 5000 fold.
