143165-09-7

Basic information

• Product Name: 1H-Imidazole-4-carbonyl chloride, 1-methyl-
• CAS NO: 143165-09-7
• Molecular Formula: C5H5ClN2O
• Molecular Weight: 144.56
• Mol File: 143165-09-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Imidazole-4-carbonyl chloride, 1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4-carbonyl chloride, 1-methyl-(143165-09-7)
• EPA Substance Registry System: 1H-Imidazole-4-carbonyl chloride, 1-methyl-(143165-09-7)

Safety Data

• Hazardous Substances Data: 143165-09-7(Hazardous Substances Data)

Usage

Classification

Imidazole derivative

Common usage

Reagent in organic synthesis

Reactivity

Highly reactive

Versatility

Versatile intermediate

Applications

Production of pharmaceuticals, agrochemicals, and other fine chemicals

Structure

Unique structure and functional groups

Synthesis

Useful for the synthesis of various heterocyclic compounds and complex organic molecules

Building block

Can be used in the creation of specialty polymers and materials

Importance

Important chemical reagent in the field of organic chemistry.

Upstream product

• 41716-18-1 1-methylimidazole-4-carboxylic acid 

Downstream Products

• 17289-19-9 methyl 1-methyl-1H-imidazole-4-carboxylate 
• 1031289-51-6 1-methyl-N-(4-oxocyclohexyl)-N-[3-(trifluoromethoxy)benzyl]-1H-imidazole-4-carboxamide 
• 1031289-49-2 N-(1,4-dioxaspiro[4.5]dec-8-yl)-1-methyl-N-[3-trifluoromethoxybenzyl]-1H-imidazole-4-carboxamide 
• 1041013-89-1 (1S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-{[(1-methyl-1H-imidazol-4-yl)carbonyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 
• 1259398-82-7 C₂₁H₂₁N₅O₃S 
• 1245711-74-3 methyl N-[(1-methyl-1H-imidazol-4-yl)carbonyl]-N-(tetrahydro-2H-pyran-4-yl)-3-(trifluoromethoxy)phenylalaninate 
• 1245711-77-6 N-[1-Hydroxy-3-[3-(trifluoromethoxy)phenyl]propan-2-yl]-1-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-4-carboxamide 
• 1366405-88-0 N-cyclobutyl-N-{1-[2-(4-fluorophenyl)pyridin-4-yl]ethyl}-1-methyl-1H-imidazole-4-carboxamide 
• 486414-83-9 C-(1-methyl-1H-imidazol-4-yl)methylamine 

Relevant articles and documents

Selective Decarboxylation of 1-Methyl-4,5-imidazoledicarboxylic Acid

The selective decarboxylation of 1-methyl-4,5-imidazoledicarboxylic acid was carried out in various solvents. 1-Methyl-5-imidazolecarboxylic acid was obtained by heating in acetic or propionic anhydride, whereas 1-methyl-4-imidazolecarboxylic acid was obtained in N,N-dimethylformamide, N,N-dimethylacetamide, or N-methylpyrrolidone or by pyrolysis.The reaction mechanism is discussed.

Copper-mediated C–H thiolation of (hetero)arenes using weakly coordinating directing group

We have developed a copper-mediated C–H thiolation of (hetero)arenes by using monodentate amide as weakly coordinating directing group. This protocol features excellent functional group tolerance and shows satisfactory compatibility with various heterocycles, such as indole, pyrrole, imidazole, pyridine, thiophene and quinoline. The robust nature of this protocol renders that it has potential value in the synthetic application.

GLYCINE TRANSPORTER INHIBITING SUBSTANCES

The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder: