143165-48-4Relevant articles and documents
Isomeric cis-cyclohexano-13-crown-4 ethers: A low-temperature 1H and 13C NMR investigation
Buchanan,Gerzain,Laister
, p. 687 - 692 (1998)
The two positionally isomeric cyclohexanotetraoxacyclotridecanes (13-crown-4 ethers) were synthesized and studied via low-temperature NMR methods. For the 1,4,8,11-tetraoxa isomer, the cyclohexane ring inversion is a degenerate process, whereas for the 1,4,7,11-tetraoxa isomer, a preference of 1.4 kJ mol-1 for the form in which the propyleneoxy group is equatorial was determined. Molecular mechanics calculations using MM+ indicated a preference of 0.6 kJ mol-1 for this conformer. Resonance assignment was facilitated by the synthesis of a selectively deuterated derivative and by COSY, HMQC and HMBC experiments. The results were compared with those for the related 10-crown-3 system and 13C chemical shift trends are discussed in terms of MM+ calculated geometries. John Wiley & Sons Ltd.
COMPOUNDS AND METHODS FOR TRANS-MEMBRANE DELIVERY OF MOLECULES
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Paragraph 0036, (2018/07/31)
A system for delivery of drugs, and especially genetic drugs such as siRNA or antisense oligonucleotides (ASO) across biological membranes is provided. It comprises a trans- membrane delivery moiety, energized by the membrane internal electrical field, an
SOLID-SUPPORTED ETHER DISULFIDES
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, (2011/08/08)
The present invention provides for compounds of Formulas I-III, and salts thereof, wherein n, m, R1, R2, R3, and R4 have any of the values defined there for in the specification. The compounds of formula I may b
