1431656-27-7Relevant articles and documents
Triflic anhydride mediated synthesis of imidazo[1,5-a]azines
Pelletier, Guillaume,Charette, Andre B.
supporting information, p. 2290 - 2293 (2013/06/26)
Imidazo[1,5-a]azines are synthesized in moderate to excellent yields using a mild cyclodehydration/aromatization reaction triggered by the use of triflic anhydride (Tf2O) and 2-methoxypyridine (2-MeOPyr). Various substitution patterns and functional groups were found to be compatible under the optimized conditions. In addition, a 5-bromo-3-aryl derivative was also shown to be active in a Sonogashira cross-coupling and direct arylation reactions. A tertiary amide was compatible as a substrate leading to the synthesis of an imidazo[1,5-a]pyridinium triflate.