1431660-67-1Relevant articles and documents
A variation of the Fischer indolization involving condensation of quinone monoketals and aliphatic hydrazines
Zhang, Jinzhu,Yin, Zhiwei,Leonard, Patrick,Wu, Jing,Sioson, Kate,Liu, Che,Lapo, Robert,Zheng, Shengping
, p. 1753 - 1757,5 (2013/04/10)
A new twist: A one-pot nitrous acid free, diazonium-free, and transition-metal-free variation of the Fischer indole synthesis has been developed. Condensation of quinone monoketals and aliphatic hydrazine hydrochlorides afforded indoles via intermediate alkylaryldiazenes. This method will complement the classical Fischer indole synthesis by providing indoles in two steps from widely available phenols under mild conditions. Copyright