143169-55-5

Basic information

• Product Name: 2,3-methanomethionine
• Synonyms: 2,3-methanomethionine
• CAS NO: 143169-55-5
• Molecular Formula: C6H11 N O2 S
• Molecular Weight: 0
• Mol File: 143169-55-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 311.4°Cat760mmHg
• Flash Point: 142.1°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2,3-methanomethionine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-methanomethionine(143169-55-5)
• EPA Substance Registry System: 2,3-methanomethionine(143169-55-5)

Safety Data

• Hazardous Substances Data: 143169-55-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H11NO2S/c1-10-3-4-2-6(4,7)5(8)9/h4H,2-3,7H2,1H3,(H,8,9)/t4-,6+/m1/s1

Upstream product

• 143122-78-5 Hexanoic acid (1R,2R)-2-tert-butoxycarbonylamino-2-carbamoyl-cyclopropylmethyl ester 
• 143169-47-5 (1S,2S)-(+)-1--2-<(hexanoyloxy)methyl>cyclopropane-1-carbonitrile 
• 143122-79-6 (1R,2R)-(-)-1--2-<(hexanoyloxy)methyl>cyclopropane-1-carbonitrile 
• 143169-49-7 (1S,2S)-(-)-1--2-<(acetylthio)methyl>cyclopropane-1-carbonitrile 
• 143169-46-4 (1S,5S)-(+)-1--2-oxo-3-oxabicyclo<3.1.0>hexane 
• 143169-45-3 (1R,5R)-(-)-1--2-oxo-3-oxabicyclo<3.1.0>hexane 
• 143169-50-0 (1S,2S)-(-)-1--2-(mercaptomethyl)cyclopropane-1-caronitrile 
• 143169-48-6 (1S,2S)-(-)-1--2-(hydroxymethyl)cyclopropane-1-carbonitrile 
• 143169-40-8 (1R,5R)-(-)-1-(tert-butoxycarbonyl)-2-oxo-3-oxabicyclo<3.1.0>hexane 
• 143169-57-7 (1S,5R)-1-carboxy-2-oxo-3-oxabicyclo[3.1.0]hexane 
• 154704-03-7 (1S,2R)-1-tert-Butoxycarbonylamino-2-methanesulfonyloxymethyl-cyclopropanecarboxylic acid tert-butyl ester 
• 143122-75-2 (1S,2R)-(-)-tert-butyl 2-(acetoxymethyl)-1-cyclopropane-1-carboxylate 
• 143122-76-3 (1S,2R)-(-)-tert-butyl 1--2-(hydroxymethyl)cyclopropane-1-carboxylate 
• 175694-64-1 methyl (1S,2R)-(-)-1-N-benzyloxycarbonylamino-2-methanesulfonyloxymethylcyclopropanecarboxylate 

Relevant articles and documents

Enantioselective total syntheses of cyclopropane amino acids: Natural products and protein methanologs

The syntheses of (-)-allo-coronamic acid, (-)-allo-norcoronamic acid, (-)-(Z)-2,3-methanohomoserine, (-)-(Z)-2,3-methanomethionine, and (2S,3R)-Cbz-cyclo-Asp-OMe have been achieved in 45-68% overall yields from suitable intermediates derived from homochiral aminopentenoates which were obtained, in turn, from D-glyceraldehyde. The key synthetic step involves the quantitative and highly diastereoselective cyclopropanation of such precursors. The factors dealing with the control of stereoselectivity are highlighted and the main features in side-chain functionalization to the respective target molecules are discussed.

Asymmetric synthesis of all four stereoisomers of 2,3-methanomethionine

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