1431697-85-6

Basic information

• Product Name: AT-7519 trifluoroacetate
• Synonyms: AT 7519 trifluoroacetate;AT7519 (trifluoroacetate);AT-7519 trifluoroacetate;4-[(2,6-Dichlorobenzoyl)amino]-N-4-piperidinyl-1H-pyrazole-3-carboxamide 2,2,2-trifluoroacetate
• CAS NO: 1431697-85-6
• Molecular Formula: C18H18Cl2F3N5O4
• Molecular Weight: 496.2678296
• Mol File: 1431697-85-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AT-7519 trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: AT-7519 trifluoroacetate(1431697-85-6)
• EPA Substance Registry System: AT-7519 trifluoroacetate(1431697-85-6)

Safety Data

• Hazardous Substances Data: 1431697-85-6(Hazardous Substances Data)

Usage

General Description

AT7519 trifluoroacetate is a potent inhibitor of cyclin-dependent kinases (CDKs), which are enzymes that play a critical role in cell cycle regulation. It acts by binding to the ATP-binding site of CDKs and inhibiting their activity, thereby blocking the progression of the cell cycle and inducing apoptosis in cancer cells. AT7519 trifluoroacetate has shown promising anticancer activity in preclinical studies, particularly against hematological malignancies such as leukemia and lymphoma. It has also been investigated for its potential to overcome drug resistance in cancer cells. Clinical trials are ongoing to evaluate the safety and efficacy of AT7519 trifluoroacetate as a treatment for various types of cancer.