1431697-94-7

Basic information

• Product Name: Lorcaserin hydrochloride
• Synonyms: 8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride (1:1);8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride;RS Lorcaserin hydrochloride;7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine,hydrochloride
• CAS NO: 1431697-94-7
• Molecular Formula: C₁₁H₁₄ClN*ClH
• Molecular Weight: 232.1495
• Product Categories: API
• Mol File: 1431697-94-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Lorcaserin hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Lorcaserin hydrochloride(1431697-94-7)
• EPA Substance Registry System: Lorcaserin hydrochloride(1431697-94-7)

Safety Data

• Hazardous Substances Data: 1431697-94-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1431697-94-7 differently. You can refer to the following data:
1. Lorcaserin hydrochloride is a hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug. It has a role as a serotonergic agonist and an appetite depressant. It contains a lorcaserin(1+).Lorcaserin (hydrochloride) is an analytical reference material categorized as an anorectic.It also decreases oxycodone intake and has positive effects on self-administration and relapse vulnerability in the rat.Lorcaserin is regulated as a Schedule IV compound in the United States.
2. (±)-8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride Hemihydrate is used to prepare and study structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Upstream product

• 1875-88-3 2-(4-Chlorophenyl)ethanol 
• 88422-94-0 N-<2-(4-chlorophenyl)ethyl>acetamide 
• 616201-80-0 (+/-)-Lorcaserin 
• 1616729-45-3 2-(3-chlorophenyl)-N-(2,2-dimethoxyethyl)propan-1-amine 
• 1082555-06-3 2-(3-chlorophenyl) propan-1-amine 
• 38171-31-2 N-methyl-2-(4-chlorophenyl)ethylamine 
• 156-41-2 4-chlorophenylethylamine 
• 167886-56-8 1-[2-(tert-butoxycarbonylamino)ethyl]4-chlorobenzene 
• 1226103-88-3 2-chloro-N-[2-(4-chlorophenyl)ethyl]-N-methylacetamide 
• 1602492-08-9 8-chloro-1,3-dimethyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one 
• 1602492-07-8 7-chloro-3,5-dimethyl-2,3-dihydro-1H-3-benzazepine 
• 1602492-06-7 8-chloro-3-methyl-1-methylidene-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one 
• 1602492-05-6 8-chloro-3-methyl-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one 

Downstream Products

• 824430-71-9 (1R,S)-8,9-dichloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine 
• 846589-98-8 Lorcaserin hydrochloride 
• 1006037-59-7 (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine hydrochloride 

Relevant articles and documents

Synthesis process of weight-reducing drug lorcaserin hydrochloride intermediate

The invention discloses a synthesis process of a weight-reducing drug lorcaserin hydrochloride intermediate (compound V), which is characterized in that p-chlorophenylethylamine is used as a raw material, acetic anhydride is subjected to acylation to prot

A Concise Synthesis of Racemic Lorcaserin

We report herein the concise synthesis of racemic lorcaserin (±)-1, which is an anti-obesity drug. The synthetic route involved the key synthesis of an asymmetrical imide intermediate 11 and its efficient reduction. Imide 11 was synthesized directly by the reaction of nitrile 9 with acid 10. The reducing system of NaBH4, AlCl3, and trimethylsilyl chloride efficiently fulfilled the reduction of imide 11 to amine 8a, which could be converted to (±)-1 via Friedel-Crafts reaction as reported. This route afforded 69% two-step yield of 8a from 9 via 11, and the concise synthesis of (±)-1 was completed in three steps. This route offers an alternative pathway to the synthesis of (±)-1 and its analogues.

PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES

The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.