1431697-96-9
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Basic information
- Product Name: CCT 241533 hydrochloride
- Synonyms: CCT 241533 hydrochloride;CCT241533 (hydrochloride);CCT-241533 hydrochloride;(3R,4S)-rel-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-alpha,alpha-dimethyl-3-pyrrolidinemethanol hydrochloride (1:1);CCT241533 HCl
- CAS NO:1431697-96-9
- Molecular Formula: C23H28ClFN4O4
- Molecular Weight: 478.9442232
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1431697-96-9.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO
- CAS DataBase Reference: CCT 241533 hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: CCT 241533 hydrochloride(1431697-96-9)
- EPA Substance Registry System: CCT 241533 hydrochloride(1431697-96-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1431697-96-9(Hazardous Substances Data)
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1431697-96-9 Usage
Description
CCT241533 is a selective inhibitor of checkpoint kinase 2 (Chk2; IC50 = 3 nM). In human cancer cell lines, CCT241533 blocks Chk2 activity and potentiates the cytotoxicity of the PARP inhibitors, rucaparib, AG-1447; and olaparib .in vitro
cct241533 inhibited chk2 with an ic50 of 3 nmol/l and showed minimal cross-reactivity against a panel of kinases at 1 mmol/l. cct241533 did not potentiate the cytotoxicity of a selection of genotoxic agents in several cell lines [1]. moreover, as the most potent chk2 inhibitor identified in the series, cct241533 showed potent selectivity (63-fold) over chk1 and low herg inhibition [2].Check Digit Verification of cas no
The CAS Registry Mumber 1431697-96-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,1,6,9 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.Calculate Digit Verification of CAS Registry Number 1431697-96:
(9*1)+(8*4)+(7*3)+(6*1)+(5*6)+(4*9)+(3*7)+(2*9)+(1*6)=179
179 % 10 = 9
So 1431697-96-9 is a valid CAS Registry Number.
1431697-96-9Upstream product
1431697-96-9Downstream Products
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CCT 241533 hydrochloride
