1431698-47-3

Basic information

• Product Name: KN-92 (hydrochloride)
• Synonyms: KN-92 (hydrochloride);KN92-HCl
• CAS NO: 1431698-47-3
• Molecular Formula: C24H26Cl2N2O3S
• Molecular Weight: 493.44584
• Mol File: 1431698-47-3.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: ≥24.65 mg/mL in DMSO; insoluble in H2O; ≥11.73 mg/mL in EtOH with gentle warming and ultrasonic
• CAS DataBase Reference: KN-92 (hydrochloride)(CAS DataBase Reference)
• NIST Chemistry Reference: KN-92 (hydrochloride)(1431698-47-3)
• EPA Substance Registry System: KN-92 (hydrochloride)(1431698-47-3)

Safety Data

• Hazardous Substances Data: 1431698-47-3(Hazardous Substances Data)

Usage

Biological Activity

kn-92 is an inactive analog of kn-93. kn-93 is the cam kinase ii inhibitor. [1]hearts were treated with the cam kinase inhibitor kn-93 or the inactive analog kn-92 (0.5 μm) for 10 min before clofilium exposure. early afterdepolarizations (eads) were largely inhibited by kn-93 contrasted to kn-92. there were little differences in parameters favoring eads such as monophasic action potential duration or heart rate in kn-92- or kn-93- treated hearts. cam kinase activity in situ increased 37% in hearts with eads compared to hearts without eads. this increase in cam kinase activity was prevented by pretreatment with kn-93. [1]in vitro, kn-93 potently suppressed rabbit myocardial cam kinase activity (calculated ki ≤ 2.58 μm), but the inactive analog kn-92 did not (ki > 100 μm). the actions of kn-93 and kn-92 on ica and other repolarizing k+currents did not illustrate preferential ead suppression by kn-93. [1]

references

1. kn-93, an inhibitor of multifunctional ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. j pharmacol exp ther. 1998 dec;287(3):996-1006.