143192-34-1Relevant articles and documents
Liver targeting compound and conjugate
-
, (2021/02/24)
The invention provides a compound, which has a structure represented by formula (3), and also provides a conjugate formed by covalently linking the compound and an active agent. The conjugate can target hepatocytes, so that the problems associated with in vivo delivery of an active agent are effectively solved, the toxicity is low, and the stability and activity of the delivered active agent are prevented from being significantly affected.
Templated synthesis of peptide nucleic acids via sequence-selective base-filling reactions
Heemstra, Jennifer M.,Liu, David R.
, p. 11347 - 11349 (2011/03/21)
(Chemical Equation Presented) The templated synthesis of nucleic acids has previously been achieved through the backbone ligation of preformed nucleotide monomers or oligomers. In contrast, here we demonstrate templated nucleic acid synthesis using a base
Synthesis, biological, and immunological properties of cyclic peptides from Plasmodium Falciparum Merozoite Surface Protein-1
Lioy, Eduardo,Suarez, Jorge,Guzmn, Fanny,Siegrist, Sibylle,Pluschke, Gerd,Patarroyo, Manuel E.
, p. 2631 - 2635 (2007/10/03)
Effective structural mimics of a functionally important epitope from the malarial Merozoite Surface Protein-1 (MSP-1) include N-backbone cyclic peptides such as 1. They mimic the interaction of MSP-1 with human erythrocytes and can be used to induce parasite-specific monoclonal antibodies.
Building Units for N-Backbone Cyclic Peptides. 1. Synthesis of Protected N-(ω-Aminoalkylene)amino Acids and Their Incorporation into Dipeptide Units
Byk, Gerardo,Gilon, Chaim
, p. 5687 - 5692 (2007/10/02)
A variety of new amino acids which contain an ω-aminoalkylene group on the Nα-amino nitrogen were synthesized by alkylation of alkylenediamines with α-halogeno acids.The reaction proceeds with inversion of configuration; thus, optically pure products were obtained when optically active α-halogeno acids were used.The N-(ω-aminoalkylene)amino acids were protected by orthogonal protecting groups to allow their incorporation into dipeptides by the "solution" techniques and into peptides by the solid-phase peptide synthesis (SPPS) methodology.A series of dipeptide analogs of Phe-Gly, Leu-Gly, Trp-Gly, Phe-Leu, and Phe-Ala in which the nitrogen of the peptide bond is alkylated by ω-aminoalkylene chains with various lengths were prepared.These new protected N-(ω-aminoalkylene)amino acids and their derived dipeptide units may be used as building blocks for conformationally constrained N-backbone cyclic peptides.
