1431973-99-7Relevant academic research and scientific papers
Iron-catalyzed directed C2-alkylation and alkenylation of indole with vinylarenes and alkynes
Wong, Mun Yee,Yamakawa, Takeshi,Yoshikai, Naohiko
, p. 442 - 445 (2015)
An iron-N-heterocyclic carbene catalyst generated from an iron(III) salt, an imidazolinium salt, and a Grignard reagent promotes alkylation and alkenylation reactions at the indole C2-position with vinylarenes and internal alkynes, respectively, via imine-directed C-H activation. The former reaction affords 1,1-diarylalkane derivatives with exclusive regioselectivity. Deuterium-labeling experiments suggest that these reactions involve oxidative addition of the C-H bond to the iron center, insertion of the unsaturated bond into the Fe-H bond, and C-C reductive elimination.
Cobalt-catalyzed ortho-alkenylation of aromatic aldimines via chelation-assisted C-H bond activation
Yamakawa, Takeshi,Yoshikai, Naohiko
, p. 4459 - 4465 (2013/06/26)
An ortho-alkenylation reaction of an aromatic aldimine with an internal alkyne is efficiently promoted by a cobalt catalyst generated from CoBr 2, triarylphosphine, and iPrMgBr. The reaction takes place under mild room-temperature co
