1431978-23-2Relevant academic research and scientific papers
Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates
Raj, Raghu,Saini, Anu,Gut, Jiri,Rosenthal, Philip J.,Kumar, Vipan
, p. 230 - 239 (2015/04/14)
Abstract The manuscript describes the synthesis of novel amide tethered 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone bifunctional hybrids and their evaluation as antimalarial agents against W2 resistant strain of Plasmodium falciparum. The antiplasmodial activity of 7-chloroquinoline-ferrocenylchalcones was found to be less than their corresponding simple chalcone conjugates. The presence of a methoxy substituent at para position of ring B on chalcones and longer alkyl chain length markedly improved the antiplasmodial profiles of the synthesized scaffolds with the most potent of the test compound exhibiting an IC50 value of 17.8 nM. Synthesis of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates.Antimalarial potency of synthesized conjugates was evaluated against W2 strain.Most potent and non-cytotoxic conjugate exhibited IC50 of 17.8 nM.
A disulfide-linked conjugate of ferrocenyl chalcone and silicon(iv) phthalocyanine as an activatable photosensitiser
Lau, Janet T. F.,Jiang, Xiong-Jie,Ng, Dennis K. P.,Lo, Pui-Chi
supporting information, p. 4274 - 4276 (2013/06/05)
A novel bis(ferrocenyl chalcone) silicon(iv) phthalocyanine has been prepared in which the disulfide linker can be cleaved by dithiothreitol. The separation of the ferrocenyl quencher and the phthalocyanine core greatly enhances the fluorescence emission,
