1432038-41-9Relevant academic research and scientific papers
Design of stable β-sheet-based cyclic peptide assemblies assisted by metal coordination: Selective homo- and heterodimer formation
Panciera, Michele,Amorín, Manuel,Castedo, Luis,Granja, Juan R.
, p. 4826 - 4834 (2013)
Metal-directed supramolecular construction represents one of the most powerful tools to prepare a large variety of structures and functions. The ability of metals to organize different numbers and types of ligands with a variety of geometries (linear, trigonal, octahedral, etc.) expands the supramolecular synthetic architecture. We describe here the precise construction of homo- and heterodimeric cyclic peptide entities through coordination of a metal (Pd, Au) and to β-sheet-type hydrogen-bonding interactions. The selective coordination properties of the appropriate metal allow control over the cross-strand interaction between the two-peptide strands. Metal tweezers: The self-assembling properties of α,γ-cyclic peptides are reinforced by metal coordination to precisely construct homo- and heterodimeric complexes. The metal coordination is able to shift the equilibrium from several nonequivalent dimers to one single ensemble (see scheme). Copyright
