1432040-88-4

Basic information

• Product Name: 6-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLIC ACID
• Synonyms: 6-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLIC ACID
• CAS NO: 1432040-88-4
• Molecular Formula: C9H6O3S
• Molecular Weight: 194.20714
• Mol File: 1432040-88-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLIC ACID(1432040-88-4)
• EPA Substance Registry System: 6-HYDROXYBENZO[B]THIOPHENE-2-CARBOXYLIC ACID(1432040-88-4)

Safety Data

• Hazardous Substances Data: 1432040-88-4(Hazardous Substances Data)

Upstream product

• 331-64-6 2-fluoro-4-methoxy-benzaldehyde 
• 187753-62-4 ethyl 6-methoxybenzo[b]thiophene-2-carboxylate 
• 1106537-69-2 ethyl 6-hydroxy-1-benzothiophene-2-carboxylate 
• 102539-79-7 6-methoxybenzo[b]thiophene-2-carboxylic acid 
• 1029720-28-2 methyl 6-hydroxybenzo[b]thiophene-2-carboxylate 

Relevant articles and documents

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication

Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current investigation, we developed a novel series of benzothiophene derivatives and their analogues (6-8) that potently inhibit the replication of both hRV-A and hRV-B strains. Compound 6g inhibited the replication of hRV-B14, A21, and A71, with respective EC50 values of 0.083, 0.078, and 0.015 μM. The results of a time-of-addition study against hRV-B14 and hRV-A16 and resistant mutation analysis on hRV-B14 implied that 6g acts at the early stage of the viral replication process, interacting with viral capsid protein. A molecular docking study suggested that 6g has a capsid-binding mode similar to that of pleconaril. Finally, derivatives of 6 also displayed significant inhibition against poliovirus 3 (PV3) replication, implying their potential inhibitory activities against other enterovirus species.

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound selected from a group consisting of a compound represented by the following Formula (1): and an agriculturally acceptable salt thereof, provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (5) and an agriculturally acceptable salt thereof is excluded: (1) 4-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (2) 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (3) 6-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (4) 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, and (5) Benzo[b]thiophene-2-carboxylic acid.