143205-42-9 Usage
General Description
(melle-4)cyclosporin, also known as MeIle4-CsA, is a synthetic derivative of cyclosporin, a powerful immunosuppressive drug. It is a cyclic nonribosomal peptide of 11 amino acids, with a modified structure at the fourth position. This modification increases the drug's binding affinity to cyclophilin and enhances its immunosuppressive properties. (melle-4)cyclosporin is used to prevent organ rejection in transplant patients and to treat autoimmune diseases such as rheumatoid arthritis and psoriasis. It works by inhibiting the activation of T-cells, which are involved in the immune response, and has been shown to be effective in reducing inflammation and damage caused by autoimmune reactions. Despite its potency, (melle-4)cyclosporin can have significant side effects, including an increased risk of infections and kidney damage, and requires careful monitoring and management by healthcare professionals.
Check Digit Verification of cas no
The CAS Registry Mumber 143205-42-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,2,0 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 143205-42:
(8*1)+(7*4)+(6*3)+(5*2)+(4*0)+(3*5)+(2*4)+(1*2)=89
89 % 10 = 9
So 143205-42-9 is a valid CAS Registry Number.
InChI:InChI=1/C62H111N11O12/c1-25-28-29-40(15)52(75)51-56(79)65-43(27-3)58(81)67(18)33-47(74)71(22)50(39(14)26-2)55(78)66-48(37(10)11)61(84)68(19)44(30-34(4)5)54(77)63-41(16)53(76)64-42(17)57(80)69(20)45(31-35(6)7)59(82)70(21)46(32-36(8)9)60(83)72(23)49(38(12)13)62(85)73(51)24/h25,28,34-46,48-52,75H,26-27,29-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b28-25+
