1432134-44-5

Basic information

• Product Name: C₃₄H₃₅BrN₂O₅
• CAS NO: 1432134-44-5
• Molecular Weight: 631.566
• Mol File: 1432134-44-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₄H₃₅BrN₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₄H₃₅BrN₂O₅(1432134-44-5)
• EPA Substance Registry System: C₃₄H₃₅BrN₂O₅(1432134-44-5)

Safety Data

• Hazardous Substances Data: 1432134-44-5(Hazardous Substances Data)

Upstream product

• 12689-26-8 ilicicolin H 
• 34256-78-5 4-bromoacetanilide 

Relevant articles and documents

Structure-activity relationship of cytochrome bc1 reductase inhibitor broad spectrum antifungal ilicicolin H

Ilicicolin H is a broad spectrum antifungal agent showing sub micro g/mL MICs against Candida spp., Aspergillus fumigatus and Cryptococcus spp. It is a potent inhibitor (C50 2-3 ng/mL) of the mitochondrial cytochrome bc1 reductase with over 1000-fold selectivity against rat liver cytochrome bc1 reductase. Structure-activity relationship of semisynthetic derivatives by chemical modification of ilicicolin H and its 19-hydroxy derivative produced by biotransformation have been described. Basic 4′-esters and moderately polar N- and O-alkyl derivatives retained antifungal and the cytochrome bc1 reductase activities. 4′,19-Diacetate and 19-cyclopropyl acetate retained antifungal and enzyme activity and selectivity with over 20-fold improvement of plasma protein binding.