1432201-03-0

Basic information

• Product Name: C₁₇H₁₄ClN₃O
• CAS NO: 1432201-03-0
• Molecular Weight: 311.771
• Mol File: 1432201-03-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₄ClN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₄ClN₃O(1432201-03-0)
• EPA Substance Registry System: C₁₇H₁₄ClN₃O(1432201-03-0)

Safety Data

• Hazardous Substances Data: 1432201-03-0(Hazardous Substances Data)

Upstream product

• 45964-97-4 1-(4-chlorophenyl)guanidine 
• 18096-70-3 3-dimethylamino-4'-methoxyacrylophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

Design and synthesis of a novel series of N,4-diphenylpyrimidin-2-amine derivatives as potent and selective PI3Kγ inhibitors

Due to the increasing evidence linking the PI3Kγ pathway to various disease states, PI3Kγ is becoming an important target for cancer treatment. Herein we designed and synthesized a novel series of N,4-diphenylpyrimidin-2-amine derivatives with low CDOCKER-INTERACTION-ENERGY and then evaluated their PI3Kγ in vitro inhibitory activities and in vitro antiproliferation assays against four human cancer cells. Among the compounds we synthesized, compound C8 (IC50 = 65 nM) demonstrated the most potent inhibitory activity against PI3Kγ kinase as well as at the cellular level, compared to the control drug TG100713 (IC50 = 127 nM). Moreover, molecular docking analysis was also performed to determine possible binding modes between PI3Kγ and the target compounds.