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1432201-03-0

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1432201-03-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1432201-03-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,3,2,2,0 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1432201-03:
(9*1)+(8*4)+(7*3)+(6*2)+(5*2)+(4*0)+(3*1)+(2*0)+(1*3)=90
90 % 10 = 0
So 1432201-03-0 is a valid CAS Registry Number.

1432201-03-0Downstream Products

1432201-03-0Relevant articles and documents

Design and synthesis of a novel series of N,4-diphenylpyrimidin-2-amine derivatives as potent and selective PI3Kγ inhibitors

Yang, Hua-Lin,Fang, Fei,Zhao, Chang-Po,Li, Dong-Dong,Li, Jing-Ran,Sun, Jian,Du, Qian-Ru,Zhu, Hai-Liang

, p. 219 - 225 (2014)

Due to the increasing evidence linking the PI3Kγ pathway to various disease states, PI3Kγ is becoming an important target for cancer treatment. Herein we designed and synthesized a novel series of N,4-diphenylpyrimidin-2-amine derivatives with low CDOCKER-INTERACTION-ENERGY and then evaluated their PI3Kγ in vitro inhibitory activities and in vitro antiproliferation assays against four human cancer cells. Among the compounds we synthesized, compound C8 (IC50 = 65 nM) demonstrated the most potent inhibitory activity against PI3Kγ kinase as well as at the cellular level, compared to the control drug TG100713 (IC50 = 127 nM). Moreover, molecular docking analysis was also performed to determine possible binding modes between PI3Kγ and the target compounds.

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