143239-04-7Relevant articles and documents
Enzymatic preparation of optically active fungicide intermediates in aqueous and in organic media
Bianchi, Daniele,Cesti, Pietro,Golini, Paolo,Spezia, Sandro,Garavaglia, Carlo,Mirenna, Luigi
, p. 176 - 180 (2007/10/02)
Pure stereoisomers of two new triazole and morpholine fungicides have been prepared starting from enzymatically synthesized chiral alcohol intermediates.Two resolution strategies compared are: lipase-catalyzed hydrolysis of corresponding acetates in water and lipase-catalyzed transesterification of alcohols in organic solvents.The antifungal activity of optically pure enantiomers of the synthesized fungicides investigated in vitro and in vivo against a variety of fungi, show an activity ratio (R-form/S-form) up to 400.