143248-63-9

Basic information

• Product Name: Sinitrodil
• Synonyms: Sinitrodil
• CAS NO: 143248-63-9
• Molecular Formula: C10H10N2O5
• Molecular Weight: 238.198
• Mol File: 143248-63-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 422.7°Cat760mmHg
• Flash Point: 209.4°C
• Appearance: /
• Density: 1.388g/cm³
• Vapor Pressure: 2.36E-07mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: Sinitrodil(CAS DataBase Reference)
• NIST Chemistry Reference: Sinitrodil(143248-63-9)
• EPA Substance Registry System: Sinitrodil(143248-63-9)

Safety Data

• Hazardous Substances Data: 143248-63-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O5/c13-10-8-3-1-2-4-9(8)16-7-11(10)5-6-17-12(14)15/h1-4H,5-7H2

Upstream product

• 119-36-8 methyl salicylate 
• 143248-39-9 3-(2'-acetoxyethyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one 
• 143248-47-9 2,3-dihydro-3-(2'-hydroxyethyl)-4H-1,3-benzoxazin-4-one 
• 24207-38-3 N-(2-hydroxyethyl)salicylamide 
• 143248-55-9 3-(2-chloroethyl)-2H-1,3-benzoxazin-4(3H)-one 

Relevant articles and documents

Benzoxazinone and benzothiazinone derivatives having cardiovascular activity

Compounds of formula I STR1 wherein R represents hydrogen, C1 -C6 alkyl, C5 -C7 cycloalkyl, methylene-dioxy or phenyl, which may be substituted by one or two groups independently selected from hydroxy, halogen, nitro, C1 -C6 alkyl or C1 -C6 alkoxy; R1 and R2 independently represent hydrogen, COOR3, --CONR4 R5, STR2 --OCONR4 R5, --OCOR3, --NR4 R5, --OCOOR6, --NR3 COR7, --NRCONR4 R5, --N=CH--NR4 R5, NO2, CN, OH, SR3, wherein R3 is hydrogen or C1 -C6 alkyl, R4 and R5 independently are hydrogen or C1 -C6 alkyl, R6 is C1 -C6 alkyl, and R7 is hydrogen, C1 -C6 alkyl or C1 -C6 alkoxy, with the proviso that R1 and R2 cannot be hydrogen at the same time; X is oxygen or sulphur; Y represents a C2 -C6 alkylene chain or a C5 -C7 cycloalkylene group; and their pharmaceutically acceptable salts are provided and their use in pharmaceutical compositions which may be used in the treatment of cardiovascular diseases.

Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity

2,3-dihydro-4H-1,3-benzoxazin-4-ones and 2,3-dihydro-4H-1,3-benzothiaxin-4-ones of formula I wherein R represents hydrogen, (C1 6)alkyl, (C5 7)cycloalkyl, phenyl, phenyl substituted by hydroxy, halogen, nitro, (C1 6)alkyl, (C1 6)alkoxy, methylenedioxy; R1 and R2 independently represent hydrogen, amide, amino, carboxy, hydroxy, nitro, ciano, mercapto; X is an oxygen or sulphur atom; Y is a (C2 6)alkylene chain or (C2 6)cycloalkylene group; and the pharmaceutically acceptable acid or basic salts thereof.