1432492-22-2

Upstream product

• 1432492-21-1 phenyl 6-O-tosyloxy-1-thio-β-D-mannopyranoside 
• 77481-63-1 phenyl-1-thio-β-D-mannopyranoside 

Downstream Products

• 1432492-28-8 3-O-benzoyl-2,4-diazido-2,4,6-trideoxy-α-D-galactopyranoside trichloroacetimidate 
• 1432492-30-2 N-(benzyloxycarbonyl)-O-(3-O-acetyl-2,4-diazido-2,4,6-trideoxy-α-D-galactopyranosyl)-L-serine methylester 
• 1432492-33-5 N-(benzyloxycarbonyl)-O-(2,4-diazido-2,4,6-trideoxy-α-D-galactopyranosyl)-L-serine methylester 
• 1432492-16-4 phenyl 2-azido-3-O-benzoyl-2,4,6-trideoxy-4-phthalimido-1-thio-β-D-galactopyranoside 
• 1446793-11-8 C₁₃H₁₃BrN₆O₃ 
• 1432492-23-3 phenyl 3-O-acetyl-2,4-diazido-2,4,6-trideoxy-1-thio-β-D-galactopyranoside 
• 1432492-24-4 phenyl 3-O-acetyl-2,4-diazido-2,4,6-trideoxy-1-thio-β-D-galactopyranoside 
• 1432492-18-6 C₁₉H₁₉N₃O₄S 
• 1432492-25-5 phenyl 2,4-diazido-3-O-benzoyl-2,4,6-trideoxy-1-thio-β-D-glucopyranoside 
• 1432492-20-0 phenyl 3-O-acetyl-6-deoxy-1-thio-β-D-mannopyranoside 
• 1432492-17-5 phenyl 3-O-benzoyl-6-deoxy-1-thio-β-D-mannopyranoside 

Relevant academic research and scientific papers

A target oriented expeditious approach towards synthesis of certain bacterial rare sugar derivatives

Bacterial rare amino deoxy sugars are found in the cell surface polysaccharides of multiple pathogenic bacterial strains, but are absent in the human metabolism. This helps in the differentiation between pathogens and host cells which can be exploited for target specific drug discovery and carbohydrate based vaccine development. The principal bacterial atypical sugar derivatives include 2-acetamido-4-amino-2,4,6-trideoxy-d-galactose (AAT), 2,4-diacetamido-2,4,6-trideoxy-d-galactose (DATDG) and N-acetylfucosamine (FucNAc). Herein, a highly streamlined protocol leading to the aforesaid derivatives is presented. The highlights of the method lie in radical mediated 6-deoxygenation along with a one-pot like protection profile manipulation on suitably derivatised d-glucosamine or d-mannose motifs to obtain a vital quinovosaminoside or rhamnoside from which rare sugar derivatives were synthesized in a diversity oriented manner.

Expeditious synthesis of bacterial, rare sugar building blocks to access the prokaryotic glycome

Bacteria have unusual glycans which are not accessible by isolation. Herein, we describe a general and divergent strategy for the synthesis of the rare, bacterial deoxy amino hexopyranoside building blocks from d-mannose. The methodology is applied to the first total synthesis of the l-serine linked trisaccharide of Neisseria meningitidis. The Royal Society of Chemistry 2013.